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The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytesKorošec, Tamara, zootehnik, 1978- ...The objective of present study was to detrermine the effect of T-2 toxin and deoxynivalenol (DON) on DNA fragmentation in spleen leukocytes and oxidative stress in chickens, and furthermore, to ... evaluate the potential of dietary nucleotides in reduction of toxininduced DNA damage. Male brother chickens were exposed to 10mg/kg feed of either T-2 toxin or DON with or without addition of dietary nucleotides. After 17 days of treatment DNA damage of spleen leukocytes was measured by Comet assay, lipid peroxidation was studied by malondialdehyde (MDA), total antioxidant status (TAS) of plasma and glutathione peroxidase (GPx) assays, and the hepatotoxicity was studied by measuring plasma liver enzyme levels (ALT, AST and GGT) levels. T-2 toxin and DON induced DNA fragmantation in chicken spleen leukocytes and supplementationwith nucleotides reduced the amount of damage only when added to T-2 toxin. In compariosn to control group, values of TAS and AST decreased significantly in the groups fed T-2 toxin with or without nucleotide supplementation. Plasma and liver MDA content in groups fed T-2 toxin and DON did not differ significantly from the control. Dietary nucleotides did not affect MDA formation when added to the diets with mycotoxins. The results obtained suggest that dietary nucleotides have the potency to reduce the extent of DNA damage indiced by the action of T-2 toxin in immune cells. This underlines their possible beneficial effect on the immune system in mycotoxin intoxication.Source: Food and chemical toxicology. - ISSN 0278-6915 (Letn. 44, št. 11, 2006, str. 1838-1844)Type of material - article, component partPublish date - 2006Language - englishCOBISS.SI-ID - 1881480
Author
Korošec, Tamara, zootehnik, 1978- |
Pajk Žontar, Tanja |
Rezar, Vida |
Levart, Alenka |
Salobir, Janez
Topics
perutnina |
kokoši |
piščanci |
prehrana živali |
oksidacijski stres |
nukleotidi |
toksini |
DNK |
poškodbe
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Korošec, Tamara, zootehnik, 1978- | 25513 |
Pajk Žontar, Tanja | 21396 |
Rezar, Vida | 20082 |
Levart, Alenka | 15194 |
Salobir, Janez | 00886 |
Source: Personal bibliographies
and: SICRIS
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