ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system [Elektronski vir]Felicijan, Tjaša ; Bogataj, Marija, 1963-Oral solid dosage forms are most frequently administered with a glass of water which empties from the stomach relatively fast, but with a certain variability in its emptying kinetics. The purpose of ... this study was thus to simulate different individual water gastric emptying (GE) patterns in an in vitro glass-bead flow-through dissolution system. Further, the effect of GE on the dissolution of model drugs from immediate-release tablets was assessed by determining the amount of dissolved drug in the samples pumped out of the stomach compartment. Additionally, different HCl solutions were used as dissolution media to assess the effect of the variability of pH of the gastric fluid on the dissolution of three model drugs: paracetamol, diclofenac sodium, and dipyridamole. The difference in fast and slow GE kinetics resulted in different dissolution profiles of paracetamol in all studied media. For diclofenac sodium and dipyridamole tablets, the effect of GE kinetics was well observed only in media, where the solubility was not a limiting factor. Therefore, GE kinetics of co-ingested water influences the drug release from immediate-release tablets, however, in certain cases, other parameters influencing drug dissolution can partly or fully hinder the expression of this effect.Source: Acta pharmaceutica. - ISSN 1846-9558 (Vol. 74, no. 2, 2024, str. 269-287)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 188738051
Author
Felicijan, Tjaša |
Bogataj, Marija, 1963-
Topics
Farmacevtske oblike |
NUK |
water gastric emptying |
gastric pH |
glass-bead dissolution system |
immediate-release tablets |
praznjenje želodca z vodo |
želodčni pH |
raztapljanje v steklenih kroglicah sistem |
tablete s takojšnjim sproščanjem
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Author | Felicijan, Tjaša ; Bogataj, Marija, 1963- |
Title | Forecasting the effect of water gastric emptying patterns on model drug release in an in vitro glass-bead flow-through system [Elektronski vir] |
Publication date | |
COBISS.SI-ID | 188738051 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
---|
![]() |
![]() |
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Felicijan, Tjaša | 52168 |
Bogataj, Marija, 1963- | 11124 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: