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Genotoxicity and heating performance of VxFe3-xO4 nanoparticles in health applicationsSanz-Sagué, Beatriz ...The applications of magnetic nanoparticles (MNPs) as biocatalysts in different biomedical areas have been evolved very recently. One of the main challenges in this field is to design affective MNPs ... surfaces with catalytically active atomic centres, while producing minimal toxicological side effects on the hosting cell or tissues. MNPs of vanadium spinel ferrite (VFe2O4) are a promising material for mimicking the action of natural enzymes in degrading harmful substrates due to the presence of active V5+ centres. However, the toxicity of this material has not been yet studied in detail enough to grant biomedical safety. In this work, we have extensively measured the structural, compositional, and magnetic properties of a series of VxFe3-xO4 spinel ferrite MNPs to assess the surface composition and oxidation state of V atoms, and also performed systematic and extensive in vitro cytotoxicity and genotoxicity testing required to assess their safety in potential clinical applications. We could establish the presence of V5+ at the particle surface even in water-based colloidal samples at pH 7, as well as different amounts of V2+ and V3+ substitution at the A and B sites of the spinel structure. All samples showed large heating efficiency with Specific Loss Power values up to 400 W/g (H0 = 30 kA/m; f = 700 kHz). Samples analysed for safety in human hepatocellular carcinoma (HepG2) cell line with up to 24h of exposure showed that these MNPs did not induce major genomic abnormalities such as micronuclei, nuclear buds, or nucleoplasmic bridges (MNIs, NBUDs, and NPBs), nor did they cause DNA double-strand breaks (DSBs) or aneugenic effects—types of damage considered most harmful to cellular genetic material. The present study is an essential step towards the use of these type of nanomaterials in any biomedical or clinical application.Source: Chemico-biological interactions. - ISSN 0009-2797 (Vol. 394, [art. no.] 110977, 1 May 2024, str. [1]-13)Type of material - article, component part ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 190594819
Author
Sanz-Sagué, Beatriz |
Sáenz-Hernández, Amaia |
Žegura, Bojana |
Štern, Alja |
Kološa, Katja |
Rozman, Iza, farmacevtka
Topics
magnetni nanodelci |
vanadijev ferit |
citotoksičnost |
genotoksičnost |
specifična absorpcijska moč |
celična živost |
magnetic nanoparticles |
vanadium ferrite |
cytotoxicity |
genotoxicity |
specific power absorption |
cell viability
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Author | Sanz-Sagué, Beatriz ... |
Title | Genotoxicity and heating performance of VxFe3-xO4 nanoparticles in health applications |
Publication date | 2024-03-24 |
COBISS.SI-ID | 190594819 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Ekotoksiologija, toksikološka genomika in karcinogeneza | P1-0245-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj novih večfunkcionalnih nanocimov na osnovi kovinskih oksidov in njihova toksikološka karakterizacija (NaNoZymSafe) | J1-4395-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Sanz-Sagué, Beatriz | ![]() |
Sáenz-Hernández, Amaia | ![]() |
Žegura, Bojana | 20767 |
Štern, Alja | 32094 |
Kološa, Katja | 29297 |
Rozman, Iza, farmacevtka | ![]() |
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