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  • Continuous glucose monitoring-based metrics and hypoglycemia duration in insulin-experienced individuals with long-standing type 2 diabetes switched from a daily basal insulin to once-weekly insulin icodec [Elektronski vir] : Post hoc analysis of ONWARDS 2 and ONWARDS 4
    Bajaj, Harpreet S. ...
    Bisphenol A (BPA) is an endocrine disruptor (ED), widely used as a comonomer or an additive in the plastics industry. It can be found in food and beverage plastic packaging, epoxy resins, thermal ... paper and other common products. To date, there have only been several experimental studies to have examined how BPA exposure affects human and mammalian follicular granulosa cells (GCs) in vitro and in vivo; the collected evidence data show that BPA negatively affects the GCs by altering steroidogenesis and gene expression, inducing autophagy, apoptosis and cellular oxidative stress through reactive oxygen species production. Exposure to BPA can also lead to abnormally constrained or elevated cellular proliferation and can even reduce cell viability. Therefore, research on EDs such as BPA is important as it provides some important insights into the causes and development of infertility, ovarian cancer and other conditions related to impaired ovarian and GC function. Folic acid, a biologic form of vitamin B9, is a methyl donor that can neutralize the toxic effects of the BPA exposure and is, as a common food supplement, an interesting option for researching its protective role against ubiquitous harmful EDs such as BPA.
    Source: Diabetes care [Elektronski vir]. - ISSN 1935-5548 (no. 4, Vol. 47, Str. 729-738)
    Type of material - e-article ; adult, serious
    Publish date - 2024
    Language - english
    COBISS.SI-ID - 192351747

    Link(s):

    https://pubmed.ncbi.nlm.nih.gov/38380954/
    DOI

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