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Compensational role between cathepsins [Elektronski vir]Pečar Fonović, Urša ; Kos, Janko, 1959- ; Mitrović, AnaCathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that ... are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches.Source: Biochimie [Elektronski vir]. - ISSN 1638-6183 (Vol. , [article no.], [in press] 2024, str. 1-51)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 193579011
Author
Pečar Fonović, Urša |
Kos, Janko, 1959- |
Mitrović, Ana
Topics
Katepsini |
Rak (bolezen) |
Vnetje |
Nevrodegenerativne bolezni |
lysosomal peptidases |
compensation |
bone resorption
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Pečar Fonović, Urša | 19170 |
Kos, Janko, 1959- | 04648 |
Mitrović, Ana | 36440 |
Source: Personal bibliographies
and: SICRIS
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