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Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre studyPires Simoes, Margarida ...Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the ... epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.Source: The Journal of infectious diseases. - ISSN 0022-1899 (Vol. , iss. , Mar. 2024, str. 1-21)Type of material - article, component part ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 194436611
Author
Pires Simoes, Margarida |
Hodcroft, Emma B |
Simmonds, Peter |
Albert, Jan |
Berginc, Nataša, 1978- |
Lunar, Maja M., 1982- |
Poljak, Mario, 1965- |
Uršič, Tina, 1980-
Topics
enterovirus D68 (EV-D68) |
okužba dihal |
enterovirus brez otroške paralize (NPEV) |
evropska mreža enterovirusov brez otroške paralize (ENPEN) |
akutna flakcidna paraliza (AFP) |
akutni flakcidni mielitis (AFM) |
nadzor |
koronavirusna bolezen, ki jo povzroča SARS-CoV-2 (COVID-19) |
enterovirus D68 (EV-D68) |
respiratory infection |
non-polio enterovirus (NPEV) |
European Non-Polio Enterovirus Network (ENPEN) |
acute flaccid paralysis (AFP) |
acute flaccid myelitis (AFM) |
surveillance |
B3-derived lineages |
coronavirus disease caused by SARS-CoV-2 (COVID-19)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Pires Simoes, Margarida | ![]() |
Hodcroft, Emma B | ![]() |
Simmonds, Peter | ![]() |
Albert, Jan | ![]() |
Berginc, Nataša, 1978- | 28077 |
Lunar, Maja M., 1982- | 54554 |
Poljak, Mario, 1965- | 11622 |
Uršič, Tina, 1980- | 25433 |
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