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Naše izkušnje pri zdravljenju kronične mieloične levkemije z imatinib mesilatom = Treatment with imatinib mesilat in chronic myelogenous leukemia - our experience
Grat, Mateja ; Vučković, Joško
Izhodišča. Kronična mieloična levkemija (KML) je maligna klonska bolezen krvotvornih matičnig celic. Pri večini bolnikov najdemo recipročno translokacijo t (9,22), katere posledica je BCR-ABL onkogen ...in onkoprotein z aktivnostjo tirozin kinaze. Posledično nastopi deregulacija poti signalne transdukcije z motnjami celičnega cikla, inhibicijo apoptoze in proliferacijo celic. ABL specifični zaviralci tirokin kinaze selektivno zavro proliferacijo malignega klona. Metode. Pri 11 bolnikih v kronični fazi KML smo uvedli imatinib 400 mg dnevno. Ocenjevali smo citogenski in hematološki odgovor ter pojavljanje neželenih učinkov zdravila. Rezultati. Z imatinibom smo dosegli dober citogenski odgovor pri 78% bolnikov, od tega pri 11% popoln citogenski odgovor. Pri vseh bolnikih je bila dosežena popolna hematološka remisija 4 tedne po uvedbi zdravila. Neželene učinke smo opazovali pri 55% bolnikov, resnejše hematološke neželene učinke pa pri 11% bolnikov. Zaključki. Pri zdravljenju bolnikov v kronični fazi KML z imatinibom smo dosegli dober citogenetski in popoln hematološki odgovor.
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