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Prevalence and treatment outcomes of childhood acute lymphoblastic leukemia in Kosovo [Elektronski vir]Pasha, Flaka ...Advances in research, including novel biomarker identification and patient stratification, have significantly improved the therapy for childhood acute lymphoblastic leukemia (ALL), though access to ... improved healthcare services varies across geographical regions. In an effort to evaluate the advances in therapeutic approaches, we performed a retrospective analysis of childhood ALL in Kosovo. Our retrospective analysis included 225 cases diagnosed between 2008 and 2023, representing 52% of 429 diagnosed childhood cancers. The average annual incidence was 14, with a median age diagnosis of seven years, and a male predominance (59.54%). Patients were categorized into risk groups, with the majority (43%) in the standard-risk category. We identified five different treatment protocols for this study period. Over 61% of patients achieved remission after the first chemotherapy cycle and we observed a 20% mortality rate. Survival analysis showed that 55% and 40% of patients achieved 2-year and 5-year event-free survival (EFS), respectively, with significant differences across risk groups. Treatment advancements significantly correlated with improved survival rates, achieving a 5-year overall survival (OS) of 88% in the currently used standardized AIEOP-BFM-2009 protocol. Our study emphasizes the need for continued research and customized care strategies to enhance clinical outcomes.Source: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 16, no. 11, 2024, 13 str.)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 196879107
Author
Pasha, Flaka |
Urbančič, Dunja, farmacevtka |
Maxhuni, Rufadie |
Krasniqi, Shaip |
Grajçevci Uka, Violeta |
Mlinarič-Raščan, Irena
Topics
Akutna limfoblastna levkemija |
Zdravljenje |
Pediatrija |
splošno preživetje |
preživetje brez dogodkov |
acute lymphoblastic leukemia |
treatment |
overall survival |
event-free survival |
pediatric
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Author | Pasha, Flaka ... |
Title | Prevalence and treatment outcomes of childhood acute lymphoblastic leukemia in Kosovo [Elektronski vir] |
Publication date | 2024-05-23 |
COBISS.SI-ID | 196879107 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin | P1-0208-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL) | MRIC UL | I0- 0022 | |
Sofinanciranje izvajanja mednarodnega infrastrukturnega projekta EATRIS | I0-E011-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Pasha, Flaka | ![]() |
Urbančič, Dunja, farmacevtka | 34512 |
Maxhuni, Rufadie | ![]() |
Krasniqi, Shaip | ![]() |
Grajçevci Uka, Violeta | ![]() |
Mlinarič-Raščan, Irena | 12443 |
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