ALL libraries (COBIB.SI union bibliographic/catalogue database)
13.
Spremembe v stromi pri maligni preobrazbi polipoidnih adenomov širokega črevesa in danke : doktorska disertacija = The stromal changes associated with the malignant change of colorectal polypoid adenomas
Vodopivec, Boris, 1951-
Backround. Tumor stroma is a specialised tissue important for the tumor growthand nutrition. We have analysed stromal changes in early polypoid colorectal adenocarcinomas (PCRC). One of the main ...questions was the difference in the stroma composition between early PCRC and benign colorectal polyps. Methods and materials. A retrospective analysis was performed on biopsies of early colorectal polypoid adenocarcinoma (Dukes A, TI=72%, T2=28%). Adenomas with early malignant change (n=25), and three control groupsof polyps with stromal changes, adenomas (n=12), juvenile polyps (n=11) and polyps connected with rectal prolapse (n+11) were included in the study. Biopsy tissue specimens, fixed in neutral formalin and embedded in paraffin, were stained with haematoxilin and eosin, and Kreyberg methods. Stromal changes were analysed by immunohistochemical methods using the following antigensČ alpha-smooth muscle actin (alpha-SMA), von Willebrand factor (vWF), desmin, fibrinoctin, collagen III, collagen IV, laminin, Ki-67, CD68 and by the reaction with lectin Ulex Europaeus agglutinin-1 (UEA-1) for alpha-L-fucose. For statistical analysis, a nonparametric Wilcoxon rank sum test and Mann-Whitney test-U were used. The criterion for the statistical significance was P<0,05. Results. We have found the following stromal changes in the early PCRC, that were significantly different from the control groups of polypsČ The number of myofibroblasts and pericytes was increased. They werearranged in multiple layers around tumor glands. In the myofibroblast cytoplasm, alpha-SMA but no desmin, was found. The orientation of myofibroplasts, pericytes and smooth muscle cells was irregular. Small vesselswere increased in number and their morphology as well as architecture were altered in a characteristic way. The capillaries were arranged around carcinomatous glands in multiple layers and showed characteristic budding in all directions. (Abstract truncated at 2000 characteristics.)
Type of material - dissertation
; adult, serious
Publication and manufacture - Ljubljana : [B. Vodopivec], 1999
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
