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New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseasesNoorden, Cornelis J. F. van ...Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also ... produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production.Source: The Journal of histochemistry and cytochemistry. - ISSN 0022-1554 (Vol. 72, iss. 5, May 2024, str. 329-352)Type of material - article, component partPublish date - 2024Language - englishCOBISS.SI-ID - 199290115
Author
Noorden, Cornelis J. F. van |
Yetkin-Arik, Bahar |
Serrano Martinez, Paola |
Bakker, Noëlle |
Breest Smallenburg, Mathilda E. van |
Schlingemann, Reinier O. |
Klaassen, Ingeborg |
Majc, Bernarda |
Habič, Anamarija |
Bogataj, Urban |
Galun, Katrin S. |
Vittori, Miloš |
Erdani-Kreft, Mateja |
Novak, Metka, biokemija, 1985- |
Breznik, Barbara, 1989- |
Hira, Vashendriya V. V.
Topics
aerobic glycolysis |
anaerobic glycolysis |
angiogenesis |
ATP synthesis |
cancer cells |
cancer stem cells |
endothelial cells |
energy metabolism |
eye diseases |
oxidative phosphorylation |
pericytes |
retina |
Warburg effect |
rak |
onkologija |
rakave celice |
bolezni oči |
metabolizem |
angiogeneza
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Author | Noorden, Cornelis J. F. van ... |
Title | New insights in ATP synthesis as therapeutic target in cancer and angiogenic ocular diseases |
Publication date | 2024-05-01 |
COBISS.SI-ID | 199290115 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial 4.0 International |
Embargo | Immediate publication for public |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Noorden, Cornelis J. F. van | 51349 |
Yetkin-Arik, Bahar | ![]() |
Serrano Martinez, Paola | ![]() |
Bakker, Noëlle | ![]() |
Breest Smallenburg, Mathilda E. van | ![]() |
Schlingemann, Reinier O. | ![]() |
Klaassen, Ingeborg | ![]() |
Majc, Bernarda | 51984 |
Habič, Anamarija | 54677 |
Bogataj, Urban | 38158 |
Galun, Katrin S. | ![]() |
Vittori, Miloš | 32060 |
Erdani-Kreft, Mateja | 15873 |
Novak, Metka, biokemija, 1985- | 32116 |
Breznik, Barbara, 1989- | 36319 |
Hira, Vashendriya V. V. | ![]() |
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