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Peroralno zdravljenje z etopozidom pri bolnicah z razsejenim rakom dojk : magistrsko deloJagodic, MonikaMetastatic breast cancer is a chronic, incurable disease. Treatment of these patients is performed with a palliative intent, and therefore it sbould be as far as possible comfortable to the patients. ... When treatment with the cytotoxicdrugs known to be most effective for brust canccr has failed, other drugs are used as the so-called salvage therapy. For such a treatment, different cytotoxic drugs, generally in combined schedules are used. In patients with metastatic breast cancer, treatment with VP-16 was found to be effective. The possibility of peroral use and moderate side effects make this treatment very suitable. Taken orally, VP-16 shows great differences in bioavailability, which renders its effects unpredictable. There are only few reports about patients and disease characteristics that influence the effectiveness of peroral VP-16 treatment. Our retrospective study included 75 patients with advanced breat cancer, who had already been treated with standard cytotoxic drugs, and received salvage chemotherapy VP-16 100 mg/day for 10 days every 3 weeks, in the period from 1993 to 1997. Peroral VP-16 treatment proved effective in 37% of patients. A significantly better responseto VP-16 was achieved in patients who had responded to previous anthracycline-containing regimens than in those in whom that treatment had been ineffective (50 % vs.17 %, respectively, p = 0,016). A better response toVP-16 was also noted in patients with a long disease-free interval, with predominant soft tissue and bone metastatic sites, with up to two metastatic sites and a long time interval between the first course of previous chemotherapy and the onset of VP-16 treatment. These ditferences, however, didnot reach the levels of statistical significance. (Abstract truncated at 2000 characters.)Type of material - master's thesisPublication and manufacture - Ljubljana : [M. Jagodic], 1999Language - slovenianCOBISS.SI-ID - 2016788
Author
Jagodic, Monika
Other authors
Čufer, Tanja, 1955-
Topics
Breast neoplasms |
Drug therapy |
Breast neoplasms |
Secondary |
Etoposide |
Pharmacology |
Dojka, novotvorbe |
Terapija z zdravili |
Dojka, novotvorbe |
Sekundaren |
Etopozid |
Farmakologija |
medicinska onkologija
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Library/institution |
City | Acronym | For loan | Other holdings |
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Institute of Oncology Ljubljana | Ljubljana | OILJ |
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MF, Central Medical Library, Ljubljana | Ljubljana | CMK |
outside loan 1 cop.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jagodic, Monika | 20051 |
Čufer, Tanja, 1955- | 12179 |
Source: Personal bibliographies
and: SICRIS
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