-
Comparison of intravenous ganciclovir and cytomegalovirus hyperimmune globulinpre-emptive treatment in cytomegalovirus-positive heart transplant recipientsVrtovec, Bojan, 1972- ...We compared the use of intravenous ganciclovir and cytomegalovirus hyperimmuneglobulin (CMVIG) as a pre-emptive treatment for cytomegalovirus (CMV)-positive heart transplant recipients. Of 59 ... CMV-seropositive adult hearttransplant recipients enrolled in Group 1,37 tested positive for pp65 antigen within 12 weeks post-transplantation. These patients were randomized to receive either intravenous ganciclovir (n = 23) or CMVIG (n = 14). Group 2 included 133 CMV-seropositive heart transplant recipients who were not tested for CMV antigenemia and who received no anti-CMV therapy. CMV disease developed in 0 of 59 patients from Group 1, and in 27 of 133 patients (20%) inGroup 2 (p = 0.0001). The incidence of superinfections was lower in Group 1 (0.28 0.46) than in Group 2 (1.10 1- 1.33) (p = 0.01). The 2 groups did not differ with regard to incidence of rejection (0.7 0.9 in Group 1 vs 1.0 1.2 in Group 2; p = NS), transplant coronary artery disease at 1 year (14% in Group 1 vs 16°/ in Group 2; p = NS) or post-transplant lymphoproliferative disease (0% in Group 1 vs 2% in Group 2; p = NS). Ganciclovir and CMVIG therapies were associated with similar rates of rejection (0.52 0.6 with ganciclovir vs 0.50 0.60 with CMVIG; p = NS), superinfection (0.30 0.48 with ganciclovir vs 0.25 0.46 with CMVIG; p = NS), and transplant coronary artery disease at 1 year <13% with ganciclovir vs 14% with CMVIG, p = NS). Thepre-emptive anti-CMV approach is superior to prophylaxis in CMV-seropositive heart transplant recipients. Both ganciclovir and CMVIG are equally effective. J Heart Lung Transplant 2004;23:461-465.Source: Journal of heart and lung transplantation. - ISSN 1053-2498 (Letn. 23, št. 4, 2004, str. 461-465)Type of material - article, component partPublish date - 2004Language - englishCOBISS.SI-ID - 20294873
Author
Vrtovec, Bojan, 1972- |
Thomas, Cynthia D. |
Radovancevic, Rajko |
Frazier, O.H. |
Radovancevic, Branislav
Topics
Heart Transplantation |
Cytomegalovirus Infections |
Prevention And Control |
Diagnosis |
Antiviral Agents |
Administration And Dosage |
Economics |
Ganciclovir |
Administration And Dosage |
Economics |
Immunoglobulins |
Administration And Dosage |
Age Factors |
Sex Factors |
Drug Costs |
Follow-Up Studies |
Immunization, Passive |
Phosphoproteins |
Treatment Outcome |
Viral Matrix Proteins |
Antivirusna zdravila |
Citomegalovirusne infekcije |
Ganciklovir |
Imunoglobulini |
Srce, presaditev |
Fosfoproteini |
Imunizacija pasivna |
Sledilne študije |
Spolni faktorji |
Starostni faktorji |
Virusne, matriksne beljakovine |
Zdravilo, cene |
Zdravljenje, izid
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Vrtovec, Bojan, 1972- | 18826 |
Thomas, Cynthia D. | ![]() |
Radovancevic, Rajko | ![]() |
Frazier, O.H. | ![]() |
Radovancevic, Branislav | ![]() |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.