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Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransferSerša, Gregor ...Electroporation is a platform technology for drug and gene delivery. When applied to cell in vitro or tissues in vivo, it leads to an increase in membrane permeability for molecules which otherwise ... cannot enter the cell (e.g., siRNA, plasmid DNA, and some chemotherapeutic drugs). The therapeutic effectiveness of delivered chemotherapeutics or nucleic acids depends greatly on their successful and efficient delivery to the target tissue. Therefore, the understanding of different principles of drug and gene delivery is necessary and needs to be taken into account according to the specificity of their delivery to tumors and/or normal tissues. Based on the current knowledge, electrochemotherapy (a combination of drug and electric pulses) is used for tumor treatment and has shown great potential. Its local effectiveness is up to 80 % of local tumor control, however, without noticeable effect on metastases. In an attempt to increase systemic antitumor effectiveness of electrochemotherapy, electrotransfer of genes with immunomodulatory effect (immunogene electrotransfer) could be used as adjuvant treatment. Since electrochemotherapy can induce immunogenic cell death, adjuvant immunogene electrotransfer to peritumoral tissue could lead to locoregional effect as well as the abscopal effect on distant untreated metastases. Therefore, we propose a combination of electrochemotherapy with peritumoral IL-12 electrotransfer, as a proof of principle, using electrochemotherapy boosted with immunogene electrotransfer as in situ vaccination for successful tumor treatment.Source: Cancer immunology and immunotherapy. - ISSN 0340-7004 (Vol. 64, no. 10, 2015, str. 1315-1327)Type of material - article, component partPublish date - 2015Language - englishCOBISS.SI-ID - 2044027
Author
Serša, Gregor |
Teissie, Justin, 1947- |
Čemažar, Maja |
Signori, Emanuella |
Kamenšek, Urška |
Marshall, Guillermo |
Miklavčič, Damijan
Topics
elektroporacija |
elektrokemoterapija |
elektrogenska terapija |
cepljenje |
electroporation |
electrochemotherapy |
gene electrotransfer |
vaccination
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source: Cancer immunology and immunotherapy. - ISSN 0340-7004 (Vol. 64, no. 10, 2015, str. 1315-1327)
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Serša, Gregor | 08800 |
Teissie, Justin, 1947- | ![]() |
Čemažar, Maja | 14575 |
Signori, Emanuella | ![]() |
Kamenšek, Urška | 28387 |
Marshall, Guillermo | ![]() |
Miklavčič, Damijan | 10268 |
Source: Personal bibliographies
and: SICRIS
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