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Sequential treatment with afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer [Elektronski vir] : an observational studyHochmair, Maximilian J ...Aim: To assess outcomes in patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer receiving sequential afatinib and osimertinib in a real-world clinical setting. Materials & ... methods: In this retrospective, observational, multicenter study, patients (n = 204) had T790M-positive disease following first-line afatinib and started osimertinib treatment [>/=]10 months prior to data entry. Primary outcome was time on treatment. Results: Overall median time on treatment was 27.6 months (90% CI: 25.9-31.3), 30.3 months (90% CI: 27.6-44.5) in Del19-positive patients and 46.7 months (90% CI: 26.8-not reached) in Asians. The 2-year overall survival was 78.9%. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib facilitates prolonged, chemotherapy-free treatment in patients with T790M acquired resistance, and is a potentially attractive strategy, especially for Del19-positive tumors.Source: Future oncology. - ISSN 1744-8301 (Vol. 14, no. 27, Nov. 2018, str. 2861-2874)Type of material - e-article ; adult, seriousPublish date - 2018Language - englishCOBISS.SI-ID - 2048432753
Author
Hochmair, Maximilian J |
Morabito, Alessandro |
Hao, Desiree |
Yang, Cheng-Ta |
Soo, Ross A |
Yang, James C-H |
Gucalp, Rasim |
Halmos, Balazs |
Wang, Lara |
Golembesky, Amanda |
Märten, Angela |
Čufer, Tanja, 1955-
Topics
Lung neoplasms |
Therapy |
Pljučne novotvorbe |
Terapija |
non-small-cell lung cancer |
afatinib |
osimertinib |
epidermal growth factor receptor |
EGFR |
observational study |
nedrobnocelični pljučni rak |
afatinib |
osimertinib |
receptor za epidermalni rastni dejavnik |
EGFR |
opazovalna raziskava
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hochmair, Maximilian J | |
Morabito, Alessandro | |
Hao, Desiree | |
Yang, Cheng-Ta | |
Soo, Ross A | |
Yang, James C-H | |
Gucalp, Rasim | |
Halmos, Balazs | |
Wang, Lara | |
Golembesky, Amanda | |
Märten, Angela | |
Čufer, Tanja, 1955- | 12179 |
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