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Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer [Elektronski vir] : updated analysis of the observational GioTag studyHochmair, Maximilian J ...Aims: Overall survival (OS) and updated time to treatment failure (TTF) analysis of patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer who received sequential ... afatinib/osimertinib in the real-world GioTag study. Patients & methods: Patients had T790M-positive disease following first-line afatinib and received osimertinib treatment (n = 203). Primary outcome was TTF. The OS analysis was exploratory. Results: Median OS was 41.3 months (90% CI: 36.8-46.3) overall and 45.7 months (90% CI: 45.3-51.5) in patients with Del19-positive tumors (n = 149); 2-year survival was 80 and 82%, respectively. Updated median TTF with afatinib and osimertinib was 28.1 months (90% CI: 26.8-30.3). Conclusion: Sequential afatinib/osimertinib was associated with encouraging OS/TTF in patients with EGFR T790M-positive non-small-cell lung cancer, especially in patients with Del19-positive tumors.Source: Future oncology. - ISSN 1744-8301 (Vol. 15, iss. 25, Sep. 2019, str. 2905-2914)Type of material - e-article ; adult, seriousPublish date - 2019Language - englishCOBISS.SI-ID - 2048610929
Author
Hochmair, Maximilian J |
Morabito, Alessandro |
Hao, Desiree |
Yang, Cheng-Ta |
Soo, Ross A |
Yang, James C-H |
Gucalp, Rasim |
Halmos, Balazs |
Wang, Lara |
Märten, Angela |
Čufer, Tanja, 1955-
Topics
Carcinoma, non-small cell lung |
Therapy |
Drug therapy |
Afatinib |
Nedrobnocelični karcinom pljuč |
Terapija |
Terapija z zdravili |
Afatinib |
osimertinib |
raziskava GioTag |
osimertinib |
GioTag study
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hochmair, Maximilian J | |
Morabito, Alessandro | |
Hao, Desiree | |
Yang, Cheng-Ta | |
Soo, Ross A | |
Yang, James C-H | |
Gucalp, Rasim | |
Halmos, Balazs | |
Wang, Lara | |
Märten, Angela | |
Čufer, Tanja, 1955- | 12179 |
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