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BDNF synthesis in cultures astrocytes is regulated by monoamines through the receptor mechanism
Lončar, Darja ...
The focus of our present study was the regulatory effects of noradrenaline (NA) and serotonin (5-HT) on BDNF synthesis in astrocytes. Examined neurotransmitters potently increased BDNF content in ...cultured astrocytes in dose- and time-dependent manner: NA (1 miM; 6 h) by 4-fold and 5-HT (1 miM; 4 h) by 2.3-fold in cortical astrocytes and by 2.8- (1 miM; 6 h) and 1.7-fold (0.5 miM; 4 h) in cerebellar astrocytes. Phentolamine (alfa-adrenergic antagonist) showed no effect whereas sotalol (beta-adrenergic antagonist) dose-dependently inhibited the stimulatoty response on BDNF induced by NA, thereby supporting the conclusion that NA-stimulated BDNF synthesis in astrocytes is a beta-adrenergic receptor mediated process. Our results thus indicate the existence of a positive feed-back loop between the activity of monoaminergic neurons and astrocytic neurotrophic support.
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