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Cyanobacterial cyclic peptides can disrupt cytoskeleton organization in human astrocytes [Elektronski vir] : a contribution to the understanding of the systemic toxicity of cyanotoxinsBubik, Anja ...The systemic toxicity of cyclic peptides produced by cyanobacteria (CCPs) is not yet completely understood. Apart from the most known damages to the liver and kidneys, symptoms of their neurotoxicity ... have also been reported. Hepatotoxic CCPs, like microcystins, as well as non-hepatotoxic anabaenopeptins and planktopeptins, all exhibit cytotoxic and cytostatic effects on mammalian cells. However, responses of different cell types to CCPs depend on their specific modes of interaction with cell membranes. This study demonstrates that non-hepatotoxic planktopeptin BL1125 and anabaenopeptins B and F, at concentrations up to 10 µM, affect normal and tumor human astrocytes (NHA and U87-GM) in vitro by their almost immediate insertion into the lipid monolayer. Like microcystin-LR (up to 1 µM), they inhibit Ser/Thr phosphatases and reorganize cytoskeletal elements, with modest effects on their gene expression. Based on the observed effects on intermediate filaments and intermediate filament linkage elements, their direct or indirect influence on tubulin cytoskeletons via post-translational modifications, we conclude that the basic mechanism of CCP toxicities is the induction of inter- and intracellular communication failure. The assessed inhibitory activity on Ser/Thr phosphatases is also crucial since the signal transduction cascades are modulated by phosphorylation/dephosphorylation processes.Source: Toxins : Elektronski vir. - ISSN 2072-6651 (Vol. 16, iss. 9, [art no.] 374, Sept. 2024, str. 1-18)Type of material - e-articlePublish date - 2024Language - englishCOBISS.SI-ID - 205590019
Author
Bubik, Anja |
Frangež, Robert |
Žužek, Monika C. |
Gutiérrez-Aguirre, Ion |
Lah Turnšek, Tamara |
Sedmak, Bojan, 1952-
Topics
astrociti |
ciklični cianobakterijski peptidi |
citoskeletna organizacija |
Ser/Thr fosfataze |
sistemska toksičnost |
cianobakterije |
astrocytes |
cyclic cyanobacterial peptides |
cytoskeletal organization |
Ser/Thr phosphatases |
systemic toxicity |
cyanobacteria
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Author | Bubik, Anja ... |
Title | Cyanobacterial cyclic peptides can disrupt cytoskeleton organization in human astrocytes [Elektronski vir] : a contribution to the understanding of the systemic toxicity of cyanotoxins |
Publication date | 2024-09-01 |
COBISS.SI-ID | 205590019 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Antikancerogeno delovanje bioaktivnih spojin cianobakterijskega izvora v nasprotju možganskih tumorjev - gliobastomov | J1-0848-2008 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Endokrini, imunski in encimski odzivi pri zdravih in bolnih živalih | P4-0053-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Database name | Field | Year |
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Bubik, Anja | 29946 |
Frangež, Robert | 12449 |
Žužek, Monika C. | 22588 |
Gutiérrez-Aguirre, Ion | 27827 |
Lah Turnšek, Tamara | 07802 |
Sedmak, Bojan, 1952- | 07736 |
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