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  • Diazenedicarboxamides as inhibitors of D-alanine-D-alanine ligase (Ddl)
    Kovač, Andreja, farmacevtka, 1979- ...
    D-Alanine-d-alanine ligase (Ddl) catalyzes the biosynthesis of an essential bacterial peptidoglycan precursor d-alanyl-d-alanine and it represents an important target for development of new ... antibacterial drugs. A series of semicarbazides, aminocarbonyldiazenecarboxylates, diazenedicarboxamides, andhydrazinedicarboxamides was synthesized and screened for inhibition of DdlBfrom Escherichia coli. Compounds with good inhibitory activity were identified, enabling us to deduce initial structure-activity relationships. Thirteen diazenedicarboxamides were better inhibitors than d-cycloserine andsome of them also possess antibacterial activity, which makes them a promising starting point for further development.
    Source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 17, no. 7, 2007, str. 2047-2054)
    Type of material - article, component part
    Publish date - 2007
    Language - english
    COBISS.SI-ID - 2063985

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