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  • Follicular sterol composition in gonadotrophin stimulated women with polycystic ovarian syndrome
    Vrtačnik-Bokal, Eda ...
    This is the first study evaluating whether oocyte development and fertilization competence are related to intrafollicular concentration of cholesterol, meiosis-activating sterols and progesterone, ... after human chorionic gonadotrophin (HCG) administration of women with polycystic ovarian syndrome (PCOS). The concentration of follicular fluid meiosis-activating sterol (FF-MAS) significantly increased in the periovulatory period from 10-14to 34-38 h after HCG administration, while the concentration of testis meiosis-activating sterol (T-MAS) decreased, suggesting a HCG-dependent inhibition of sterol ?14-reductase. There was no correlation between follicular lanosterol, FF-MAS, T-MAS, and progesterone concentrations and the presence or absence of MII oocytes. Interestingly, free cholesterol level was significantly lower and FF-MAS/cholesterol and progesterone/cholesterol ratiossignificantly higher in follicles containing MII oocytes compared to follicles from which oocytes were not retrieved. Yet, fertilization and embryoquality did not correlate with follicular sterols. This knowledge shouldbe beneficial for the implementation of protocols for in vitro maturation process, usually used in PCOS patients.
    Source: Molecular and cellular endocrinology. - ISSN 0303-7207 (Letn. 249, št. 1-2, 2006, str. 92-98)
    Type of material - article, component part
    Publish date - 2006
    Language - english
    COBISS.SI-ID - 20979673

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