ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Development and validation of a liquid chromatography tandem mass spectrometry assay for determination of raloxifene and its metabolites in human plasmaTrontelj, Jurij ...This paper describes the development and validation of a method for the detection of raloxifene (Ral) and its two glucuronide metabolites, raloxifene-6-glucuronide (M1) and raloxifene-4_-glucuronide ... (M2), in human plasma samples. Both glucuronides were synthesized enzymatically, purified and used as authentic standards. The assay involves a simple solid phase extraction (SPE) procedure of 0.5mL of human plasma and subsequent analysis byLC-MS-MS. The recoveries were higher than 71% and chromatographic separationof all the analytes was accomplished in less than 7 min. Linear ranges (r2 > 0.99) were found from 0.200 to 340 _gžL, from 1.600 to 2720 _gžL and from 0.088 to 60.00 _gžL, for M1, M2 and Ral, respectively. The limits of detection achieved were 8, 11 and 6 ngžL for M1, M2 and Ral, respectively. Themethod presented was successfully applied to a genetic polymorphism study of 47 plasma samples from women taking Evista (raloxifene hydrochloride).Source: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. - ISSN 1570-0232 (vol. 855, no. 2, 2007, str. 220-227)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 2107505
Author
Trontelj, Jurij |
Bogataj, Marija, 1963- |
Marc, Janja |
Mrhar, Aleš
Topics
raloksifen glukolorid |
raloksifen hidroklorid |
plazma vzorci |
LC/MS/MS
![loading ... loading ...](themes/default/img/ajax-loading.gif)
source: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. - ISSN 1570-0232 (vol. 855, no. 2, 2007, str. 220-227)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Trontelj, Jurij | 23420 |
Bogataj, Marija, 1963- | 11124 |
Marc, Janja | 12189 |
Mrhar, Aleš | 06086 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: