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Influence of polymers on the bioavailability of microencapsulated celecoxibHomar, Miha ...Celecoxib, a selective COX-2 inhibitor, primarily used in treatment of osteoarthritis, rheumatoid arthritis and acute pain was encapsulated in microparticles composed of various polyesters, ... polymethacrylates or cellulose derivatives used alone or blended. The influence of polymers on microparticle mean diameter, encapsulation efficiency and in vitro and in vivo celecoxib release was investigated. Microparticles were in the size range 11-37 m. Encapsulation efficiency was optimal due to poor aqueous solubility of celecoxib. Considering in vitro release, microparticles could be divided into drug delivery systems with fast and slow release profiles. Microparticles prepared with poly- -caprolactone, Eudragitr RS and low viscosity ethylcellulose, together with physical mixture of celecoxib with lactose and Celebrexr, were tested in vivo. Relative bioavailability of celecoxib was below 20% in all cases and was probably the consequence of a slow in vivo release of celecoxib from microparticles or low wettability in the case of Celebrexr and physical mixture.Source: Journal of microencapsulation. - ISSN 0265-2048 (Vol. 24, Issue 7, 2007, str. 621-633)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 2155121
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Homar, Miha | 25600 |
Ubrich, Nathalie | ![]() |
Ghazouani El, Fatima | ![]() |
Kristl, Julijana | 09032 |
Kerč, Janez | 12942 |
Maincent, Philippe | ![]() |
Source: Personal bibliographies
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