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  • Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma : where are we?
    Samuels, Stuart E. ...
    HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV%) OPC. This review summarizes and discusses several of the controversies regarding the management ... of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.
    Source: European archives of oto-rhino-laryngology. - ISSN 0937-4477 (Vol. 273, iss. 10, 2016, str. 2877-2894)
    Type of material - article, component part
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 2172283
    DOI

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