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  • Should patients with laryngeal small cell neuroendocrine carcinoma receive prophylactic cranial irradiation?
    Coca-Pelaz, Andrés ...
    While small cell neuroendocrine carcinomas (SCNCs) most often arise in the lung, extrapulmonary SCNCs arise in a variety of locations%including the head and neck region. In particular, laryngeal ... SCNCs%while rare tumors%are nevertheless recognized as distinct lesions. The rarity of laryngeal SCNC gives rise to two distinct difficulties: first (particularly with small biopsy specimens), laryngeal SCNC can be difficult to diagnose by routine light microscopy; second, limited experience with these tumors can make the crafting of a treatment plan for individual patients difficult. As regards the first problem, pathologic diagnosis is greatly enhanced by the application of immunohistochemistry. The second problem%crafting a successful treatment strategy%presents a much larger difficulty. It is tempting to extrapolate from experience with the (more common) pulmonary SCNC in search of a strategy applicable to laryngeal SCNC; such an extrapolation, however, may not be uniformly successful. In particular, while a combination of radiation therapy and chemotherapy appears to be as valuable in the treatment of extrapulmonary as it is in the treatment of pulmonary SCNC, prophylactic cranial irradiation (PCI)%which has enjoyed some success in the treatment of some patients with pulmonary SCNC%does not appear to have similar utility in patients with laryngeal SCNC. Accordingly, the use of PCI does not appear to have a role to play at this point in time in the treatment of patients with laryngeal SCNC.
    Source: European archives of oto-rhino-laryngology. - ISSN 0937-4477 (Vol. 273, iss. 10, 2016, str. 2925-2930)
    Type of material - article, component part
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 2172539
    DOI

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