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Napovedni dejavniki za prizadetost regionalnih bezgavk pri bolnikih z zgodnjim rakom želodca : magistrska naloga
Repše, Aljaž
Background: Endoscopic treatment of early gastric cancer patients has been growing constantly since the first presentation of endoscopic mucosal resection as a possibility for radical treatment. ...Endoscopic mucosal resectionis relatively simple, unexpensive, has low complication rate and offers substantially better quality of life than classical operative therapy. Lymph node metastases are quite often in patients with early gastric cancer but negative lymph nodes are essential for successful treatment. Accurate evaluation of regional lymph nodes is beyond possibilities of diagnostic procedures currently used, so patients for endoscopic treatment have to be chosen by clinico-pathological features, which help to determinate the possibility of lymph node involvement. Patients and methods: 158 early gastriccancer patients were treated in Clinical centre Ljubljana from Jan 1st 1983 to Dec 31st 1997: 156 patents were operated on, 2 were treated endoscopically. Importance of several clinico-pathological predictive factors for lymph node involvement were first tested by chi-square test and then included in multivariate model. ResultsČ 24 out of 156 (15,4%) resected patients had positive regional lymph nodes. Univariate analysis showed statistically significant correlation to depth of infiltration (p = 0,001 >, histological type by Lauren (p = 0,035) and degree of diferentiation - Grade (p = 0,015 ). Borderline significance was established for size of the lesion (p = 0,059) and gender (p = 0,072). Multivariate anlysis proved the importanceof depth of infiltration (p = 0,0005), of histological type by Lauren (p = 0,0087) and partly of the size of the lesion (p = 0,1355) as prognostic factors for regional lymph node involvement. Relative risk in submucosal EGC is 7,4 times greater than that in mucosal EGC. Diffuse type has4,5 times and mixed 5,2 times the risk in intestinal type. (Abstract truncated at 2000 characters).
Type of material - master's thesis
Publication and manufacture - Ljubljana : [A. Repše], 2000
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