ALL libraries (COBIB.SI union bibliographic/catalogue database)
PDF
  • Cytoskeleton and vesicle mobility in astrocytes
    Potokar, Maja, 1973- ...
    Exocytotic vesicles in astrocytes are increasingly viewed as essential in astrocyte-to-neuron communication in the brain. In neurons and excitable secretory cells, delivery of vesicles to the plasma ... membrane for exocytosis involves an interaction with the cytoskeleton, in particular microtubules and actin filaments. Whether cyioskeletal elements affect vesicle mobility in astrocytes is unknown. We labeled single vesicles with fluorescent atrial natriuretic peptide and monitored their mobility in rat astrocytes with depolymerized microtubules, actin, and intermediate filaments and in mouse asirocytes deficient in the intermediate filament proteins glial fibrillary acidic protein and vimentin. In asirocytes, as in neurons, microtu6ules participated in directional vesicle mobility, and actin filaments played an important role in this process. Depolymerization of intermediate filaments strongly affected vesicle trafficking and in their absence the fraction of vesicles with directional mobility was reduced.
    Source: Traffic : the international journal of intracellular transport. - ISSN 1398-9219 (Letn. 8, 2007, str. 12-20)
    Type of material - article, component part
    Publish date - 2007
    Language - english
    COBISS.SI-ID - 22326489
    DOI

Shelf entry