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  • Firing regulation of fast-spiking interneurons by autaptic inhibition
    Guo, Daqing ...
    Fast-spiking (FS) interneurons in the brain are self-innervated by powerful inhibitory GABAergic autaptic connections. By computational modelling, we investigate how autaptic inhibition regulates the ... firing response of such interneurons. Our results indicate that autaptic inhibition both boosts the current threshold for action potential generation and modulates the input-output gain of FS interneurons. The autaptic transmission delay is identified as a key parameter that controls the firing patterns and determines multistability regions of FS interneurons. Furthermore, we observe that neuronal noise influences the firing regulation of FS interneurons by autaptic inhibition and extends their dynamic range for encoding inputs. Importantly, autaptic inhibition modulates noise-induced irregular firing of FS interneurons, such that coherent firing appears at an optimal autaptic inhibition level. Our results reveal the functional roles of autaptic inhibition in taming the firing dynamics of FS interneurons.
    Source: Europhysics letters : EPL. - ISSN 0295-5075 (Vol. 114, no. 3, 2016, str. 30001-p1-30001-p6)
    Type of material - article, component part ; adult, serious
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 22329864
    DOI

source: Europhysics letters : EPL. - ISSN 0295-5075 (Vol. 114, no. 3, 2016, str. 30001-p1-30001-p6)
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