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Design and synthesis of novel N-benzylidenesulfonohydrazide inhibitors of MurC and MurD as potential antibacterial agents
Frlan, Rok ...
A series of novel N-benzylidenesulfonohydrazide compounds were designed and synthesized as inhibitors of UDP-N-acetylmuramic acidČL-alanine ligase (MurC) and ...UDP-N-acetylmuramoyl-L-alanineČD-glutamate ligase (MurD) from E. coli, involved in the biosynthesis of bacterial cell-walls. Some compounds possessedinhibitory activity against both enzymes with IC50 values as low as 30 [micro]M. In addition, a new, one-pot synthesis of amidobenzaldehydes is reported.
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