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  • Fecal short-chain fatty acids are associated with obesity in gestational diabetes [Elektronski vir]
    Molan, Katja ...
    Background: Short-chain fatty acids (SCFAs), which are produced by the microbial fermentation of undigested carbohydrates, play an important role in the metabolism and physiology of the host. SCFAs ... are involved in the regulation of maternal metabolism during pregnancy and influence weight gain, glucose metabolism, and metabolic hormones. Methods: In 2017, women who were treated for gestational diabetes mellitus (GDM) at the University Medical Centre Ljubljana were invited to participate in a longitudinal study. A total of 45 women were included in this study and comprehensively phenotyped. During the second and third trimester of pregnancy, the women with GDM provided fecal samples for SCFA analysis. The samples were analyzed by high-performance liquid chromatography for the simultaneous determination of acetate, propionate, and butyrate. Results: SCFA concentrations in feces differed between overweight/obese and normal-weight women with GDM. Acetate and propionate concentrations were significantly higher in pregnant women who were overweight or obese before pregnancy compared to normal-weight women but butyrate concentrations were not. Butyrate was elevated in the third trimester in the group with excessive gestational weight gain. Conclusions: The relationship between SCFAs and obesity is complex, and the association between SCFAs and GDM remains to be clarified. Regardless of the conflicting publications on the role of SCFAs, our study showed that higher acetate and propionate levels were associated with the weight categories of overweight or obesity before pregnancy and higher butyrate levels were associated with excessive gestational weight gain.
    Source: Biomedicines [Elektronski vir]. - ISSN 2227-9059 (Vol. 13, iss. 2, [article no.] 387, 2025, str. 1-13)
    Type of material - e-article ; adult, serious
    Publish date - 2025
    Language - english
    COBISS.SI-ID - 225946115

    Link(s):

    https://www.mdpi.com/2227-9059/13/2/387
    Repository of colleges and higher education institutions - REVIS
    DOI

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