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Sprememba vazomotorne funkcije koronarnih in perifernih arterij pri bolnikih s koronarno aterosklerozo
Čerček, Miha
Background Endothelial injury and the consequent endothelial dysfunction initiate the atherosclerotic process. One of the manifestations of endothelialdysfunction is attenuation of endothelium ...dependant vasomotion (EOV). Many studies showed that factors which induce dilator response in presence of intact endothelium, cause less vasodilation and even vasoconstriction in patients with atherosclerosis. This impairment of EOV was observed already in early phases of atherosclerotic process. It seems to involve the entire arterial tree. Function of vascular smooth muscle is also impaired in atherosclerosis. The degree of the impairment can be determined bythe evaluation of endothelium non-dependant vasomotion (ENV). ENV is inducedby factors acting directly on the vascular smooth muscle, without any endothelial itage of atherosclerotic process the ENV becomes impaired. It is also not clear whether the impairment of ENV is generalised or limited to the sites of atherosclerotic plaques. In our study, we compared EOV with ENV, and evaluated the generalisation of their impairment in patients with coronary artery disease. Methods We examined 15 patients with coronary artery disease. EOV was assessed with the cold pressor test (CPT) and with the cuff dilation test, while nitroglycerin (200 micro g intracoronary bolus injection and 0,4mgsublingually) was used to test ENV. The extent of the atherosclerotic process and the vascular response to provocative stimuli of coronary arteries were determined angiographically, while ultrasound measurements were performedfor evaluating the changes in brachial artery. Results CPT caused elevation of heart rate and arterial blood pressure. Coronary arteries constricted in response to CPT, while brachial artery diameter did not change significantly. Aplicarion of nitroglycerin lowered arterial blood pressure andincreased heart rate. (Abstract truncated at 2000 characters).
Type of material - research report
Publication and manufacture - Ljubljana : [M. Čerček], 2000
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