Matematično modeliranje odziva sklopljenih celic beta na stimulacijo z glukozo : diplomsko delo; Mathematical modeling of the response of coupled beta cells to stimulation with glucose : graduation thesis

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Matematično modeliranje odziva sklopljenih celic beta na stimulacijo z glukozo : diplomsko delo = Mathematical modeling of the response of coupled beta cells to stimulation with glucose : graduation thesis

Bajt, Martina

V diplomskem delu preučujemo delovanje modela sklopljenih celic beta. Te endokrine celice se nahajajo v Langerhansovih otočkih in izločajo inzulin ter s tem uravnavajo raven glukoze v krvi. Samo ... delovanje teh celic je zelo kompleksno in sestoji iz številnih med seboj povezanih dinamičnih procesov. Zavoljo boljšega razumevanja se pri preučevanju pogosto poslužuje modeliranja in preučevanja modelov. V nalogi je podrobneje opisana fiziologija Langerhansovih otočkov in pregled razvoja modelov celic beta. V nadaljevanju predstavimo eksperimentalne tehnike, ki se uporabljajo za snemanje aktivnosti celic beta v akutnih rezinah trebušne slinavke miši, in večcelični model, s katerim smo izvajali simulacije. Rezultati pokažejo, da napoved modela dobro sovpada z eksperimentalnimi opažanji, v kolikor se upošteva heterogenost celic beta in časovni zamik, ki je posledica metabolnih procesov v celicah.

Type of material - undergraduate thesis ; adult, serious

Publication and manufacture - Maribor : [M. Bajt], 2016

Language - slovenian

COBISS.SI-ID - 22801160

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Digital Library of the University of Maribor – DLUM

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Other authors
Gosak, Marko, 1982- | Stožer, Andraž

Availability in libraries

Library/institution	City	Acronym	For loan	Other holdings
Miklošič Library FPNM, Maribor	Maribor	PEFMB	reading room 1 cop.

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Links to authors' personal bibliographies	Links to information on researchers in the SICRIS system
Bajt, Martina
Gosak, Marko, 1982-	28405
Stožer, Andraž	32132

Source: Personal bibliographies and: SICRIS

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