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Model ortodontskega premika zob pri podgani = A model of orthodontic tooth movements in rats
Sprogar, Špela ; Drevenšek, Gorazd ; Drevenšek, Martina
Background: The aim of this study was to select the most suitable model for studying the mechanism of orthodontic tooth movement in rats and evaluating how this is affected by drugs. Materials and ...methods: The study was performed on male Wistar rats. Two different methods of placing the superelastic closed coil spring were compared as to the ability to ensure a constant force. The accuracy of measurement of distances between teeth was evaluated with the intraclass correlation coefficient (ICC). Tooth movement was compared between groups of animals using 25 cN and 50 cN coil springs. Superelastic properties of the coil spring were tested with a calibration experiment. Results: A constant force was made possible by additional fixation of the coil spring accomplished by passing the surgical wire through a predrilled hole in the approximal surfaces of both upper incisors. ICC values (0.92 +- 0.02) showed that reliability of measurement was within the standards. The amount of tooth movement produced with the 25 cN spring did not differ significantly from thatobtained with the 50 cN spring, only the shapes of the curves representingtooth movement were different. The coil spring exerted a constant force in the extension range of 3-8 mm. Conclusion: The results show that the selected animal model is suitable for studying orthodontic tooth movement.
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