-
Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulationAlessi, Marie-Christine ...Oobjective: Because obesity and insulin resistance (IR) are strongly associated with liver steatosis (LS), we investigated the relation between thedegree of LS and plasminogen activator inhibitor-1 ... (PAI-1) in ob/ob mice, in C57/BL6 mice with alcoholic LS, and in severely obese humans. Methods and results: In both mouse models, plasma PAI-1 levels were associated with PAI-1 expression in the liver and with the degree of LS. Liver PAI-1 antigen was associated with the tumor necrosis factor receptor-II (TNFRII) antigen, whereas association with TNF antigen content was found in ob/ob mice only. No significant correlation between plasma PAI-1 and PAI-1 expression in adipose tissue of ob/ob mice was observed. Furthermore, the relation between plasma PAI-1 levels and body weight was positive in ob/ob mice but negative in C57/BL6 mice (both P<0.001). In humans, PAI-1 levels were correlated with the degree of LS, and 26% of plasma PAI-1 activity was independently explained by LS and serum insulin levels. Conclusions: Plasma PAI-1 levels are more closelyrelated to fat accumulation and PAI-1 expression in the liver than in adipose tissue. In steatotic liver, PAI-1 antigen content is associated with those of TNF and TNFRII. Therefore, we suggest that TNF pathway dysregulation in LS could be involved in increased plasma PAI-1 in obesity with IR.Source: Atherosclerosis, thrombosis, and vascular biology [Elektronski vir]. - ISSN 1524-4636 (Letn. 23, št. 7, 2003, str. 1262-1268)Type of material - article, component partPublish date - 2003Language - englishCOBISS.SI-ID - 23095769
Author
Alessi, Marie-Christine |
Bastelica, Delphine |
Mavri, Alenka |
Morange, Pierre-François. |
Berthet, Bruno |
Grino, Michel |
Juhan-Vague, Irene
Topics
Plasminogen Activator Inhibitor 1 |
Fatty Liver |
Insulin Resistance |
Receptors, Tumor Necrosis Factor |
Adipose Tissue |
Body Weight |
Obesity |
Body Mass Index |
Mice, Inbred C57bl |
Insulinska rezistenca |
Maščobno tkivo |
Plazminogen aktivator, inhibitor 1 |
Receptorji, tumorje nekrotizirajoči faktor |
Zamaščena jetra |
Debelost |
Miši seva C57BL |
Telesna masa, indeks |
Telesna teža
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Alessi, Marie-Christine | ![]() |
Bastelica, Delphine | ![]() |
Mavri, Alenka | 14642 |
Morange, Pierre-François. | ![]() |
Berthet, Bruno | ![]() |
Grino, Michel | ![]() |
Juhan-Vague, Irene | ![]() |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.