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  • Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
    Juhan-Vague, Irene ...
    Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a core feature of insulin-resistance syndrome (IRS). Atherothrombotic complications in IRS are partly attributed to impaired ... fibrinolysis caused by increased plasma PAI-1 levels. Although the etiology of IRS is far from being explained,the clustering of inflammation, adipose tissue accumulation and insulin resistance suggests an etiopathological link. Proinflammatory cytokines might regulate PAI-1 expression in IRS; however, more studies are needed to confirm this complex mechanism in humans. Furthermore, modifying PAI-1 expression by PAI-1 inhibitors provides a new challenge and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes.
    Source: Journal of thrombosis and haemostasis. - ISSN 1538-7933 (Letn. 1, št. 7, 2003, str. 1575-1579)
    Type of material - article, component part
    Publish date - 2003
    Language - english, slovak
    COBISS.SI-ID - 23096537

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