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Synthesis and biological evaluation of N-acylhydrazones as inhibitors of MurC and MurD ligasesŠink, Roman ...The Mur ligases have an essential role in the intracellular biosynthesis of bacterial peptidoglycan, and they represent attractive targets for the design of novel antibacterials. A series of ... compounds with an N-acylhydrazone scaffold were synthesized and screened for inhibition of the MurC and MurD enzymes from Escherichia coli. Compounds with micromolar inhibitory activitiesagainst both MurC and MurD were identified, and some of them also showed antibacterial activity.Source: ChemMedChem : Chemistry Enabling Drug Discovery. - ISSN 1860-7179 (Vol. 3, iss. 9, 2008, str. 1362-1370)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 2360177
Author
Šink, Roman |
Kovač, Andreja, farmacevtka, 1979- |
Tomašič, Tihomir |
Škedelj, Veronika, 1983- |
Boniface, Audrey |
Bostock, Julieanne M. |
Chopra, Ian |
Blanot, Didier |
Peterlin-Mašič, Lucija |
Gobec, Stanislav, 1970- |
Zega, Anamarija
Topics
inhibitorji |
Mur ligaze |
N-acilhidrazoni |
protibakterijske učinkovine
source: ChemMedChem : Chemistry Enabling Drug Discovery. - ISSN 1860-7179 (Vol. 3, iss. 9, 2008, str. 1362-1370)
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Šink, Roman | 28862 |
Kovač, Andreja, farmacevtka, 1979- | 27782 |
Tomašič, Tihomir | 28334 |
Škedelj, Veronika, 1983- | 29903 |
Boniface, Audrey | |
Bostock, Julieanne M. | |
Chopra, Ian | |
Blanot, Didier | |
Peterlin-Mašič, Lucija | 19317 |
Gobec, Stanislav, 1970- | 15284 |
Zega, Anamarija | 18633 |
Source: Personal bibliographies
and: SICRIS
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