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Effect of melatonin on apoptosis, proliferation and differentiation of urothelial cells after cyclophosphamide treatmentZupančič, Daša ; Jezernik, Kristijan ; Vidmar, GajMelatonin was recently shown to have protective effects against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) by diminishing bladderoxidative stress. HC is accompanied by destruction of the ... bladder urothelium and followed by apoptosis and rapid regeneration via proliferation and differentiation of urothelial cells, reaching complete restoration of normal urothelium in three weeks. Therefore, the effect of melatonin on apoptosis, proliferation and differentiation of urothelial cells, during destruction and regeneration of the urothelium three-weeks after a single doseCP treatment, was studied. F344 male rats were injected intraperitoneally with saline (control group) or melatonin (Mel group) or a single dose of CP (100 mg/kg; CP group) or melatonin (10 mg/kg) with CP (Mel + CP group). Melatonin co-treatment with CP significantly reduced apoptosis and increased proliferation of urothelial cells at day 1 and thus prevented extensive loss of cells from the urothelium. However, proliferation indices at days 4 and 7 after melatonin and CP co-treatment suddenly dropped and therefore the development of hyperplasia was prevented. Melatonin co-treatment with CP also resulted in earlier differentiation of superficial urothelial cells. Melatoninseems to have protective effect against CP-induced urothelial damage and a favorable impact on regeneration and restoration of normal urothelium, since it reduces the number of apoptotic and proliferating urothelial cells and results in their earlier differentiation.Source: Journal of pineal research. - ISSN 0742-3098 (Letn. 44, št. 3, 2008, str. 299-306)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24044505
Author
Zupančič, Daša |
Jezernik, Kristijan |
Vidmar, Gaj
Topics
Bladder |
Drug Effects |
Pathology |
Apoptosis |
Urothelium |
Ki-67 Antigen |
Cell Division |
Cell Differentiation |
Cyclophosphamide |
Immunohistochemistry |
Microscopy, Electron, Scanning |
Rats, Inbred F344 |
Urotelij |
Ki-67 antigen |
Celična delitev |
Sečni mehur |
Apoptoza |
Celična diferenciacija |
Imunohistokemija |
Miši seva F344 |
Mikroskopija elektronska, vrstična |
Ciklofosfamid
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Database name | Field | Year |
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Zupančič, Daša | 20343 |
Jezernik, Kristijan | 05277 |
Vidmar, Gaj | 17837 |
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