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The angiotensin converting enzyme I/D polymorphism in long distance runnersJaklič, Helena, 1977- ...Aim: There is an assumption that ACE I/D polymorphism represents one of the possible genetic factors that might be associated with sports excellence. Recent studies have identified an increased ... frequency of I allele in elite endurance athletes, long distance runners, rowers and mountaineers. The aim ofthis study was to test the hypothesis that the ACE I/D polymorphism is associated with enhanced endurance performance. Methods: We examined this hypothesis by determining ACE I/D allele frequency in 215 marathon runners, 222 half-marathon runners and 18 inline skaters classified by performance (marathon competition results). ACE genotype and allele frequencies were compared with 252 healthy controls. Results: ACE genotype frequency in the whole cohort did not differ from that in the sedentary controls (P < 0.56). However, there was an increase of the I/I genotype incidence amongst successful marathon runners scoring on places from 1st to 150th (P < 0.01). These findings were confirmed in the group of inline skaters, similarly demonstrating an increase of the I/I genotype (P < 0.01). There was no association found between half marathon runners and the ACE genotype (P < 0.59). Conclusions: An excess of the I allele in long distance runners confirms the association between the ACE I/D polymorphism and endurance sportsperformance.Source: Journal of Sports Medicine and Physical Fitness. - ISSN 0022-4707 (Letn. 46, št. 3, 2006, str. 509-513)Type of material - article, component partPublish date - 2006Language - englishCOBISS.SI-ID - 24153817
Author
Jaklič, Helena, 1977- |
Dzurenková, Dagmar |
Selingerova, M. |
Bohuš, B. |
Timkoničova, B. |
Kovacs, L.
Topics
Running |
Adult |
Age Distribution |
Aged |
Aspartic Acid |
Child |
Gene Frequency |
Genotype |
Isoleucine |
Linear Models |
Peptidyl-Dipeptidase A |
Genetics |
Physical Endurance |
Genetics |
Predictive Value Of Tests |
Skating |
Slovakia |
Epidemiology |
Tek |
Starostna porazdelitev |
Aspartna kislina |
Drsanje |
Otrok |
Izolevcin |
Starostniki |
Genska frekvenca |
Odrasli |
Genotip |
Linearni modeli |
Peptidil-dipeptidaza A |
Telesna vzdržljivost |
Napovedna vrednost testov |
Slovaška
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Database name | Field | Year |
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Jaklič, Helena, 1977- | 26061 |
Dzurenková, Dagmar | ![]() |
Selingerova, M. | ![]() |
Bohuš, B. | ![]() |
Timkoničova, B. | ![]() |
Kovacs, L. | ![]() |
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