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  • Disturbed estrogen and progesterone action in ovarian endometriosis
    Šmuc, Tina, 1980- ...
    Endometriosis is a very common disease in pre-menopausal women, where defective metabolism of steroid hormones plays an important role in its development and promotion. In the present study,we have ... examined the expression of 11 estrogen and progesterone metabolizing enzymes and their corresponding receptors in samples of ovarian endometriomas and control endometrium. Expression analysis revealed significant up-regulation of enzymesinvolved in estradiol formation (aromatase, sulfatase and all reductive17alpha-hydroxysteroid dehydrogenases) and in progesterone inactivation (AKR1C1 and AKR1C3).Among the estrogen and progesterone was up-regulated, and therewas no signreceptors, ERalpha was down-regulated, ER
    Type of material - conference contribution
    Publish date - 2009
    Language - english
    COBISS.SI-ID - 24638937