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  • CREM modulates the circadian expression of CYP51, HMGCR, and cholesterogenesis in the liver
    Ačimovič, Jure ...
    We show for the first time that isoforms of the cAMP response element modulator Crem, regulate the circadian expression of Cyp51 and other cholesterogenic genes in the mouse liver. In the wild type ... mice the expressionof Cyp51, Hmgs, Fpps, and Sqs is minimal between CT12 and CT16 and peaks between CT20 and CT24. Cyp51, Fpps, and Sqs lost the circadian behavior in Crem-/- livers while Hmgcr is phase advanced from CT20 to CT12. This coincides with a phase advance of lathosterol/cholesterol ratio, as detected by GC-MS. Overexpression of CREMtau and ICER has little effect on the Hmgcr proximal promoter while they influence expression from the CYP51 promoter. Ourdata indicate that Crem-dependent regulation of Cyp51 in the liver results in circadian expression of this gene. We propose that cAMP signaling might generally be involved in the circadian regulation of cholesterol synthesis on the periphery.
    Source: Biochemical and biophysical research communications. - ISSN 0006-291X (Issue 1, Vol. 376, 2008, str. 206-210)
    Type of material - article, component part
    Publish date - 2008
    Language - english
    COBISS.SI-ID - 24714457
    DOI

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