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Could cytokines levels or adhesion molecules expression be predictor of IFN-ß treatment response in multiple sclerosis patients?Šega, Saša, dr. med., nevrologinja, 1962- ...Objective: Some patients with relapsing-remitting multiple sclerosis (RRMS) donot respond to treatment with interferon-beta and continue to have relapses and new enhancing lesions on MRI. The markers ... which would predict the treatment response are still not known. The objectives of the study were to compare cytokines levels (IFN-gamma, IL-4, IL-6, IL-10) and expression of adhesion molecules before and during treatment in responders and nonrespondersto IFN-beta treatment. Methods: Twenty-nine patients with RRMS were enrolled in the study. Cytokine levels were evaluated by ELISA in supernatants of IONO/PMA activated PBMC cultures (IFN-gamma, IL-4, IL-6, IL-10), and by flow cytometry (intracellular IFN-gamma, IL-4 and IL-2R expression) before and during treatment. Expression of adhesion molecules (VLA-4, ICAM-1) was evaluated by flow cytometry (CD49+ and CD54+) before and during treatment. Results: Only 9 of 29 patients were responders to treatment according to definition (no relapse in the first 2 years of treatment). We found significant differences in the expression of IL-2R after 1 month of treatment, intracellular IFN-gamma after 6 months of treatment and IL-10 levelin nonactivated PBMC cultures after 1 week of treatment. Conclusion: We concluded that the differences we had found between responders and nonresponders are most probably incidental and not predictive of treatment response. Our study shows that cytokines levels and expression of adhesion molecules cannot be used as markers for treatment response.Source: Clinical neurology and neurosurgery. - ISSN 0303-8467 (Letn. 110, 2008, str. 947-950)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24857561
Author
Šega, Saša, dr. med., nevrologinja, 1962- |
Horvat, Alenka, 1967- |
Rot, Uroš, 1967- |
Wraber-Herzog, Branka |
Ihan, Alojz
Topics
Multiple Sclerosis |
Drug Therapy |
Interferon-Beta |
Interleukin-4 |
Interleukin-6 |
Interleukin-10 |
Interferon Type Ii |
Enzyme-Linked Immunosorbent Assay |
Monocytes |
Cell Adhesion Molecules |
Flow Cytometry |
Interlevkin-6 |
Interferon-beta |
Multipla skleroza |
Interlevkin-10 |
Interlevkin-4 |
Inteferon tip II |
Celična adhezija, molekule |
Encimsko-vezani imunosorbentni test |
Monociti |
Pretočna citometrija
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Šega, Saša, dr. med., nevrologinja, 1962- | 08752 |
Horvat, Alenka, 1967- | 14075 |
Rot, Uroš, 1967- | 15441 |
Wraber-Herzog, Branka | 04890 |
Ihan, Alojz | 10337 |
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