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Animal deoxyribonucleoside kinases : 'forward' and 'retrograde' evolution of their substrate specificityPiškur, Jure, 1960-2014 ...Deoxyribonucleoside kinases, which catalyse the phosphorylation of deoxyribonucleosides, are present in several copies in most multicellular organisms and therefore represent an excellent model to ... study gene duplicationand specialisation of the duplicated copies through partitioning ofsubstrate specificity. Recent studies suggest that in the animal lineage oneof the progenitor kinases, the so-called dCK/dGK/TK2-like gene, was duplicated prior to separation of the insect and mammalian lineages. Thereafter, insects lost all but one kinase, dNK (EC 2.7.1.145), which subsequently, through remodelling of a limited number of amino acid residues, gained a broad substrate specificity.Source: FEBS letters. - ISSN 0014-5793 (Letn. 560, št. 1/3, 2004, str. 3-6)Type of material - article, component partPublish date - 2004Language - englishCOBISS.SI-ID - 25362137
Author
Piškur, Jure, 1960-2014 |
Sandrini, Michael P.B. |
Knecht, Wolfgang |
Munch-Petersen, Birgitte
Topics
Evolution, Molecular |
Amino Acid Sequence |
Animals |
Conserved Sequence |
Dna |
Chemistry |
Molecular Sequence Data |
Nucleic Acid Precursors |
Chemistry |
Phosphorylation |
Phosphotransferases (Alcohol Group Acceptor) |
Chemistry |
Genetics |
Metabolism |
Phylogeny |
Point Mutation |
Sequence Homology, Amino Acid |
Structure-Activity Relationship |
Substrate Specificity |
Evolucija molekularna |
Filogeneza |
Struktura-aktivnost, razmerje |
Substrat, specifičnost |
Molekulsko zaporedje, podatki |
Živali |
Shranjeno zaporedje |
Fosforilacija |
Zaporedna homolognost aminokislin |
Nukleinska kislina, predstopnje |
DNA |
Aminokislinsko zaporedje |
Fosfotransferaze (alkoholno skupino prejemnik) |
Točkovna mutacija
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Piškur, Jure, 1960-2014 | 31275 |
Sandrini, Michael P.B. | ![]() |
Knecht, Wolfgang | ![]() |
Munch-Petersen, Birgitte | ![]() |
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