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Anti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipientsLevičnik-Stezinar, Snežna ...Background/Aims: Occult hepatitis B infection (OBI) in blood donations is not considered infectious when anti-HBs is present. Methods: Four months after transfusion of eight blood components during ... coronary arterial bypass surgery,a 59-year-old patient developed acute hepatitis B. A second 71-year-old patient transfused with a red cell concentrate (RCC) from one of these donations had early HBV infection 7 months post-transfusion. Samples were tested for HBV serological markers and HBV DNA was quantified and sequenced. Results: One implicated donation contained anti-HBc, anti-HBs (12 IU/L) and 180 IU/ml of HBV DNA. Previous and subsequent samples contained 3-10times lower viral load and slightly variable anti-HBs. Two previous donations did not cause HBV infection. Recipients of the FFP and RCC from the index donation were both HBV infected and carried genotype D strains with sequences identical to the donor strain. Conclusions: Despite anti-HBs, an OBIcarrier transmitted HBV to two immunocompetent transfusion recipients.Source: Journal of hepatology. - ISSN 0168-8278 (Letn. 48, št. 6, 2008, str. 1022-1025)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 25614553
Author
Levičnik-Stezinar, Snežna |
Rahne-Potokar, Urška |
Candotti, Daniel |
Lelie, Nico |
Allain, Jean-Pierre, M.D.
Topics
Aged |
Antibodies, Viral |
Blood |
Blood Transfusion |
Adverse Effects |
Dna, Viral |
Blood |
Hepatitis B |
Blood |
Diagnosis |
Transmission |
Hepatitis B Virus |
Genetics |
Immunology |
Hepatitis B, virus |
Hepatitis B |
Starostniki |
Protitelesa virusna |
Krvna transfuzija |
DNA virusna
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Database name | Field | Year |
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Levičnik-Stezinar, Snežna | 14341 |
Rahne-Potokar, Urška | 20608 |
Candotti, Daniel | ![]() |
Lelie, Nico | ![]() |
Allain, Jean-Pierre, M.D. | ![]() |
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