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Fused late endocytic compartments and immunostimulatory capacity of dendritic-tumor cell hybridomasGabrijel, Mateja ...Late endocytic compartments, containing MHC class II molecules in antigen presenting cells, fuse to each other in order to deliver antigens to these molecules. We have shown previously that fusion of ... late endocytic compartmentstakes place also in hybridomas. Therefore, we investigate here whether the level of fused late endocytic compartments affects the immunostimulatory capacity of hybridomas obtained by the electrofusion of dendritic and tumor cells. The level of fused late endocytic compartments in a single hybridoma cell was assessed and samples of electrofused cells were then cocultured with autologous T cells, resulting in the priming of naive T cells. To test the immunostimulatory capacity of hybridoma cells, T-cell-induced cytotoxicity of tumor cells was assayed. The results demonstrate that in vitro cytotoxic T cell responses are enhanced if a higher percentage of fused late endocytic compartments is present in the cell population of electrofused hybridoma cells.Source: The journal of membrane biology. - ISSN 0022-2631 (Letn. 229, št. 1, 2009, str. 11-18)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 25624281
Author
Gabrijel, Mateja |
Bergant Marušič, Martina |
Kreft, Marko |
Jeras, Matjaž |
Zorec, Robert, 1958-
Topics
Hybridomas |
Dendritic Cells |
Caco-2 Cells |
Endocytosis |
Immunization |
T-Lymphocytes, Cytotoxic |
Immunohistochemistry |
Microscopy, Confocal |
Dendritične celice |
Imunizacija |
Caco-2 celice |
Hibridomi |
Endocitoza |
Limfociti T citotoksični |
Imunohistokemija |
Mikroskopija konfokalna
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Gabrijel, Mateja | 23345 |
Bergant Marušič, Martina | 22361 |
Kreft, Marko | 15666 |
Jeras, Matjaž | 01302 |
Zorec, Robert, 1958- | 03702 |
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