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Trends in survival after childhood cancer in Slovenia between 1957 and 2007Pohar Perme, Maja ; Jereb, BertaObjectives: To evaluate childhood cancer survival in Slovenia, to provide results comparable to ACCIS studies, and to study the effect of recorded variables on 5-year survival. Methods: The data are ... registry-based and presenta unique collection in terms of control and homogeneity. Survival was explored using Kaplan-Meier estimates and the Cox model. Restricted cubic splines were used to illustrate the nonlinearity of the age and year of diagnosis effect for the four chosen diagnoses. Results: The data set includes 1827 children examined from 1957 to 2002 with the follow-up ending 2007. The overall 5-year survival increased from 0.26 (95%CI š0.21, 0.33đ) before 1973 to 0.8 (95% CI š0.74, 0.85đ) for patients diagnosed in the period 1998-2002. It is best for Hodgkin disease and leukemia; for non-Hodgkin lymphoma (NHL) and intracranial and intraspinal neoplasms (CNS) the rate of improvement has been slowing down since 1990. Survival is significantly associated with age at diagnosis for patients with leukemia, CNS, NHL, and neuroblastoma (p < .001), the association varies between diseases. Hazard decreases with age for children with CNS and NHL, increases for children withneuroblastoma, and is quadratic with its lowest point at the age of about 5 years for children with leukemia. Conclusion: The survival experience in Slovenia compares well with those of large samples in the United States SEER program 1975-1995 and the data collected by ACCIS from 62 population-based cancer registries in Europe. The hazard of dying has been decreasing constantly, mainly due to improvements in leukemia treatment.Source: Pediatric hematology and oncology. - ISSN 0888-0018 (Vol. 26, no. 1/4, 2009, str. 275-286)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 25676249
Author
Pohar Perme, Maja |
Jereb, Berta
Topics
Child |
Child, preschool |
Neoplasms |
Mortality |
Proportional hazards models |
Registries |
Statistics and numerical data |
Survival rate |
Trends |
Proporcionalni modeli tveganja |
Otrok |
Otrok predšolski |
Preživetje, stopnja |
Novotvorbe |
Registri
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Pohar Perme, Maja | 23437 |
Jereb, Berta | 05318 |
Source: Personal bibliographies
and: SICRIS
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