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Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritisBohanec Grabar, Petra ...OBJECTIVES: Glutathione S-transferases (GST); GST-mu1 (GSTM1), GST-pi1 (GSTP1)and GST-theta1 (GSTT1) have peroxidase activity towards cytotoxic metabolites produced in inflammatory reactions, the ... main feature of rheumatoidarthritis (RA). Genetic polymorphisms in GSTM1, GSTP1 and GSTT1 modify the enzyme conjugation capacity and may be associated with the activityof RA. METHODS: A genotyping approach was used to analyze GSTM1-0, GSTT1-0 and GSTP1 Ile105Val and Ala114Val polymorphisms in 213 RA patients. Disease activity was assessed by the disease activity score of 28 joint counts (DAS28) twice for each patient and mean DAS28 values were calculated. RESULTS: The patients with GSTT1-0 genotype had a higher risk for developing high activity RA than the patients with GSTT1 genes present (p=0.028, OR=2.761, 95% CI=1.114-6.843). An interaction between the GSTT1 polymorphism and smoking was observed. In the group of smokers, the carriers of a homozygous deletion GSTT1 had an 8.5-fold higher risk for developing high disease activity than the patients with the GSTT1-1 genotype (p=0.004, OR=8.640, 95% CI=1.995-37.426). GSTM1 and GSTP1 polymorphisms were not associated with the disease activity. CONCLUSION: Our results suggest that thepresence of the GSTT1-0 genotype contributed to higher disease activity in RA patients. The risk for developing highly active RA was the highest in smokers with the GSTT1-0 genotype.Source: Clinical and experimental rheumatology. - ISSN 0392-856X (Vol. 27, no. 2, 2009, str. 229-236)Type of material - article, component part ; adult, seriousPublish date - 2009Language - englishCOBISS.SI-ID - 25816281
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source: Clinical and experimental rheumatology. - ISSN 0392-856X (Vol. 27, no. 2, 2009, str. 229-236)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bohanec Grabar, Petra | 25438 |
Logar, Dušan, 1951- | 10080 |
Tomšič, Matija, 1959- | 13601 |
Rozman, Blaž, 1944- | 07180 |
Dolžan, Vita | 11711 |
Source: Personal bibliographies
and: SICRIS
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