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The effect of glibenclamide on acetylcholine and sodium nitroprusside induced vasodilatation in human cutaneous microcirculationVodošek Hojs, Nina ; Štrucl, Martin ; Cankar, Ksenija, 1965-Objective: KATP channels have an important regulatory role in resting vascular tone and during hypoxia. Their role in endothelium dependent and independent vasodilatation in human skin ... microcirculation is less known. Methods: We monitored the laser-Doppler (LD) response in 14 healthy male volunteers on the skin of the forearm. In the case of endothelium dependent vasodilatation [acetylcholine (ACh) induced], a saline solution (used as control) or a solution of glibenclamide (KATP channel blocker) were randomly injected each into a distinct measurement site on different forearms followed by the iontophoresis of ACh. In the case of endothelium dependent vasodilatation with the inhibition of prostaglandin production, diclofenac (cyclooxygenase inhibitor) or the combination of diclofenac and glibenclamide were randomly injected each into a distinct measurement site on different forearms followed by the iontophoresis of ACh. In the case of endothelium independent vasodilatation [sodium nitroprusside (SNP) induced], a saline solution or glibenclamide were randomly injected each into a distinct measurement site on different forearms, iontophoresis of SNP followed. Results: Glibenclamide alone, diclofenac alone or the combination of glibenclamide and diclofenac reduced the LD flux values during rest and after ACh application (P<0Æ05). The reduction of LD flux in ACh mediated vasodilatation was greatest when using the combination of glibenclamide and diclofenac. In the case of SNP application, there was also a significantly lower LD flux rise for glibenclamide in comparison with the saline solution (P<0Æ05). Conclusions: KATP channels play an important role in human cutaneous vasodilatation induced by ACh and SNP.Source: Clinical physiology and functional imaging. - ISSN 1475-0961 (Vol. 29, no. 1, 2009, str. 38-44)Type of material - article, component part ; adult, seriousPublish date - 2009Language - englishCOBISS.SI-ID - 25860825
Author
Vodošek Hojs, Nina |
Štrucl, Martin |
Cankar, Ksenija, 1965-
Topics
mikrožilje |
koža |
vazodilacija |
K-ATP kanali |
cutaneous microcirculation |
skin |
vasodilation |
K-ATP channels
source: Clinical physiology and functional imaging. - ISSN 1475-0961 (Vol. 29, no. 1, 2009, str. 38-44)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Vodošek Hojs, Nina | 36118 |
Štrucl, Martin | 09557 |
Cankar, Ksenija, 1965- | 15243 |
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