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Cytotoxic and haemolytic steroidal glycosides from the Caribbean sponge Pandaros acanthifoliumRegalado, Erik L. ...Six new steroidal saponins, pandarosides K-M (1-3) and their methyl esters (4-6), were isolated as minor components, after a careful chemical reinvestigation of the Caribbean sponge Pandaros ... acanthifolium. Their structures were established on the basis of spectroscopic analyses and comparison with the data obtained from previous metabolites of this family. All new compounds showed moderate to weak activity against four parasitic protozoa. Additionally, these compounds and previously reported pandarosides and acanthifoliosides were tested on three human tumour cell lines, and their haemolytic and liposome permeabilizing activity were assessed. Two pandarosides exhibited moderate to strong cytotoxic effect, while three acanthifoliosides showed strong haemolytic activity.Source: Steroids. - ISSN 0039-128X (Vol. 76, iss. 12, 2011, str. 1389-1396)Type of material - article, component part ; adult, seriousPublish date - 2011Language - englishCOBISS.SI-ID - 2610511
Author
Regalado, Erik L. |
Turk, Tom, 1959- |
Tasdemir, Deniz |
Gorjanc, Manca |
Kaiser, Marcel |
Thomas, Olivier |
Fernández, Rogelio |
Amade, Philippe
Topics
Anticarcinogenic agents |
Chemistry |
Pharmacology |
Antiprotozoal agents |
Chemistry |
Pharmacology |
Cell line, tumor |
Hemolytic agents |
Chemistry |
Pharmacology |
Magnetic resonance spectroscopy |
Molecular structure
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Regalado, Erik L. | ![]() |
Turk, Tom, 1959- | 06905 |
Tasdemir, Deniz | ![]() |
Gorjanc, Manca | ![]() |
Kaiser, Marcel | ![]() |
Thomas, Olivier | ![]() |
Fernández, Rogelio | ![]() |
Amade, Philippe | ![]() |
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