Functional characterization of N-terminally GFP-tagged GLP-1 receptor
Bavec, Aljoša ; Ličar, Alenka
The glucagon-like peptide-l receptor (GLP-l receptor) mediates important effects on peripheral tissues and the central nervous system. It seems one of the most promising therapeutic targets for ...treatment of diabetes mellitus type2. Surprisingly, very little is known about the cellular mechanisms that regulate its function in vivo. One of the approaches to study receptor dynamics, expression, or signaling is using GFP-tagged fluorescent proteins. In this study, we synthesized and characterized N-terminally GFP-tagged GLP-l (GFP-GLP-l) receptor in eHO cells. We demonstrated that GFP-GLP-l receptor is weakly expressed in the plasma membranes and is functionally coupled to adenylyl cyclase via heterotrimeric G-proteins, similarly as its wild type.
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