-
Association of cytokine gene polymorphisms with psoriasis in cases from the Nile delta of EgyptSettin, Ahmad ...Background: Psoriasis is a chronic inflammatory skin disease with an immunogenetic background. This study was planned to check for the association of polymorphisms related to cytokine genes TNF-alpha ... 308(G/A), IL-10.1082(G/A), IL-6-174(G/C), and IL-1Ra (VNTR) with psoriasis in cases fromEgypt. Methods: This study included 46 cases with psoriasis recruited fromthe Department of Dermatology, University Hospitals, Nile Delta region of Egypt. They included 14 males and 32 females with a mean age SD of 46.68 12.16 years and a range of 15 to 70 years. Their genotypes were compared to 98healthy controls of matched age and sex from the same locality. Genotyping was done through DNA amplification using PCR with sequence-specific primers for polymorphic alleles. Results: Compared to controls, cases showed a significantly higher frequency of certain genotypes including IL-6.174 CC (p <0.001, OR = 6.7), IL-10.1082 GG (p < 0.05, OR = 5.1), and TNF-alpha 308 GG (p< 0.05, OR = 3.7). Combined heterozygosity for IL-10 GA, IL-6 GC, and TNF GAshowed a significant low frequency among the cases studied. Conclusion: Genetic polymorphisms related to the IL6, IL10, and TNF-alpha genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management.Source: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 18, no. 3, 2009, str. 105-112)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 26520281
Author
Settin, Ahmad |
Hassan, Hanaa |
El-Baz, Rizk |
Hassan, Tahia
Topics
Psoriasis |
Genetics |
Polymorphism (Genetics) |
Cytokines |
Polymerase Chain Reaction |
Alleles |
Tumor Necrosis Factor |
Interleukin-10 |
Interleukin-6 |
Interleukin-1 |
Egypt |
Polimerazna, verižna reakcija |
Polimorfizem (genetika) |
Citokini |
Psoriaza |
Aleli |
Tumor nekrotizirajoči faktor |
Interlevkin-6 |
Interlevkin-1 |
Egipt |
Interlevkin-10
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Settin, Ahmad | ![]() |
Hassan, Hanaa | ![]() |
El-Baz, Rizk | ![]() |
Hassan, Tahia | ![]() |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.