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Anti-NGF treatment reduces bone resorption in periodontitisGašperšič, Rok, 1972- ...Periodontitis is characterized by periodontal tissue destruction, including the alveolar bone. One of its critical components is the release of pro-inflammatory neuropeptides from sensory nerve ... endings innervating the periodontium. Since nerve growth factor (NGF) has been reported to up-regulateneuropeptides in sensory neurons, we hypothesized that it would be increased in ligature-induced periodontitis in rats, and that systemic NGF neutralization would reduce the periodontitis-associated alveolar bone resorption. Real-time PCR analysis disclosed a statistically significant time-dependent up-regulation of NGF mRNA in gingiva during 2 weeks of periodontitis. Interestingly, NGF up-regulation was also detected in the contralateral gingiva. In addition, immunohistochemistry of trigeminal ganglion neurons innervating the gingivomucosa demonstrated increased expression of TrkA receptor for NGF. Systemic anti-NGF treatment during periodontitis significantly reduced interleukin-1beta expression in gingiva and bilateral alveolar bone resorption. This suggests that NGF promotes periodontal inflammation and implicates a possible use of anti-NGF treatment in periodontitis.Source: Journal of dental research. - ISSN 0022-0345 (Letn. 89, št. 5, 2010, str. 515-520)Type of material - article, component partPublish date - 2010Language - englishCOBISS.SI-ID - 26759641
Author
Gašperšič, Rok, 1972- |
Kovačič, Uroš, 1975- |
Glišović, Špela, nevrobiologija, 1979- |
Cör, Andrej |
Skalerič, Uroš, 1945-2023
Topics
Periodontitis |
Alveolar Bone Loss |
Nerve Growth Factors |
Antagonists And Inhibitors |
Interleukin-1 |
Trigeminal Ganglion |
Pathology |
Polymerase Chain Reaction |
Rna, Messenger |
Immunohistochemistry |
Rats, Wistar |
Parodontitis |
Trigeminusov ganglij |
Živec, rastni faktorji |
Interlevkin-1 |
Alveolarna kost, izguba |
Polimerazna, verižna reakcija |
RNA, prenašalna |
Podgane, Wistar |
Imunohistokemija
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Gašperšič, Rok, 1972- | 19210 |
Kovačič, Uroš, 1975- | 22360 |
Glišović, Špela, nevrobiologija, 1979- | 26145 |
Cör, Andrej | 11308 |
Skalerič, Uroš, 1945-2023 | 03370 |
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