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  • Anti-NGF treatment reduces bone resorption in periodontitis
    Gašperšič, Rok, 1972- ...
    Periodontitis is characterized by periodontal tissue destruction, including the alveolar bone. One of its critical components is the release of pro-inflammatory neuropeptides from sensory nerve ... endings innervating the periodontium. Since nerve growth factor (NGF) has been reported to up-regulateneuropeptides in sensory neurons, we hypothesized that it would be increased in ligature-induced periodontitis in rats, and that systemic NGF neutralization would reduce the periodontitis-associated alveolar bone resorption. Real-time PCR analysis disclosed a statistically significant time-dependent up-regulation of NGF mRNA in gingiva during 2 weeks of periodontitis. Interestingly, NGF up-regulation was also detected in the contralateral gingiva. In addition, immunohistochemistry of trigeminal ganglion neurons innervating the gingivomucosa demonstrated increased expression of TrkA receptor for NGF. Systemic anti-NGF treatment during periodontitis significantly reduced interleukin-1beta expression in gingiva and bilateral alveolar bone resorption. This suggests that NGF promotes periodontal inflammation and implicates a possible use of anti-NGF treatment in periodontitis.
    Source: Journal of dental research. - ISSN 0022-0345 (Letn. 89, št. 5, 2010, str. 515-520)
    Type of material - article, component part
    Publish date - 2010
    Language - english
    COBISS.SI-ID - 26759641
    DOI

source: Journal of dental research. - ISSN 0022-0345 (Letn. 89, št. 5, 2010, str. 515-520)
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