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Elevated second-trimester free beta-hCG as an isolated finding and pregnancy outcomesBrajenović-Milić, Bojana ...Objective: To investigate the relationship between unexplained elevated second-trimester free beta-human chorionic gonadotropin (beta-hCG) levels and pregnancy complications as well as adverse ... pregnancy outcomes. Methods: The study cohort comprised 2,110 non-smoking women with chromosomal and structurally normal fetuses at low-risk for both Down's syndrome (risk <1:250)and neural tube defects (maternal serum alpha-fetoprotein <2.0 MoM). A free beta-hCG value of > or =2.0 MoM was used to define the populations with elevated levels of free beta-hCG. Descriptive statistics, chi2 test, Fisher's exact test, and logistic regression analysis were used for statistical analysis, and p < 0.05 was considered statistically significant. Results: The mean maternal age of the study group was significantly lower than in controls (27.9 +/- 4.3 and 30.6 +/- 5.1 years, respectively, p < 0.05), while the proportion of primigravidas was significantly higher compared to that of controls (p < 0.05). After adjustment of the 2 groups according to maternal age and parity, we observed an increased incidence of preeclampsia among womenwith elevated free beta-hCG levels in relation to controls (p < 0.05). However, a logistic regression analysis demonstrated that the free beta-hCG level was not a predictor of the occurrence of preeclampsia. No significant relationship was found with the incidence of gestational diabetes, oligohydramnios, polyhydramnios, pregnancy-related hypertension, intrauterine growth retardation, preterm delivery, spontaneous abortion and stillbirths (p > 0.05).Source: Fetal diagnosis and therapy. - ISSN 1015-3837 (Letn. 19, št. 6, 2004, str. 483-487)Type of material - article, component partPublish date - 2004Language - englishCOBISS.SI-ID - 26882777
Author
Brajenović-Milić, Bojana |
Tišlarić, Dubravka |
Žuvić-Butorac, Marta |
Bačić, Josip, medicina |
Petrović, Oleg |
Ristić, Smiljana |
Mimica, Marko |
Kapović, Miljenko
Topics
Pregnancy Outcome |
Biological Markers |
Chorionic Gonadotropin, Beta Subunit, Human |
Blood |
Cohort Studies |
Pregnancy |
Pregnancy Complications |
Blood |
Epidemiology |
Pregnancy Trimester, Second |
Retrospective Studies |
Risk Factors |
Smoking |
Nosečnost, izid |
Nosečnost, drugo tromesečje |
Biološki označevalci |
Nosečnost, komplikacije |
Retrospektivne študije |
Horionski gonadotropin, beta podenota, človeka |
Kajenje |
Kohortne študije |
Nosečnost |
Dejavniki tveganja
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Brajenović-Milić, Bojana | |
Tišlarić, Dubravka | |
Žuvić-Butorac, Marta | |
Bačić, Josip, medicina | |
Petrović, Oleg | |
Ristić, Smiljana | |
Mimica, Marko | |
Kapović, Miljenko | 32606 |
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